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In general, Xyrem intermittent courses of Paraplatin should not be repeated until leukocyte, neutrophil, and platelet counts have recovered. Marrow suppression is also increased in patients with impaired kidney function. Although no conclusive efficacy data exist with the following schedules of Paraplatin, lengthening the duration of single intravenous administration Xyrem 24 hours or dividing the total dose over 5 consecutive daily pulse doses has resulted in reduced emesis. Because there is a possibility Xyrem toxicity in nursing infants secondary to Xyrem treatment of Xyrem mother, it is recommended that breast feeding be discontinued if the mother is treated with Paraplatin (carboplatin aqueous solution) INJECTION.

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High intravenous exposure also produces diplopia, paresthesia, confusion, and syncope. In addition to general supportive measures, continuous ECG monitoring may be warranted in the event of overdose. Severe tremor, unsteady gaitincoordination, dysphasia, Xyrem hallucinations have been reported in cases of overdose with Ranexa. Ranolazine has anti-ischemic and antianginal effects that Xyrem not depend upon reductions in heart rate Xyrem blood pressure. Xyrem does not affect the rate-pressure product, a measure of myocardial work, at maximal exercise.

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