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A WIDE RANGE OF WEIGHT-BASED DOSES OF PROMETHAZINE HYDROCHLORIDE TABLETS, USP HAVE RESULTED IN RESPIRATORY DEPRESSION IN THESE PATIENTS. Periactin and agranulocytosis have been reported, usually when promethazine hydrochloride has been used in association Periactin other known marrow-toxic agents. In pediatric patients who are acutely ill associated with dehydration, there is an increased susceptibility to dystonias with the use of promethazine Periactin. When given Periactin with promethazine Periactin tablets, USP the dose of barbiturates should be reduced Periactin at least one-half, and the dose of narcotics should be reduced by one-quarter to one-half. Although antihistamines have been found to produce fetal mortality in rodents, the pharmacological effects of histamine in the rodent do not parallel those in man.
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Contraception must begin 4 weeks prior to initiating treatment with Thalomid, during therapy, during dose interruptions and continuing for 4 weeks following discontinuation of Thalomid therapy. In addition, there were no major differences in thalidomide PK between patients with Periactin renal disease and healthy volunteers. Periactin, no dosage adjustment is needed for patients with renal impairment or patients on dialysis. There is Periactin specific antidote for a thalidomide overdose. Periactin is an equal mixture of the Periactin and R-() forms and, therefore, has a net optical rotation of zero.
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