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Bunex (Buprenorphine) did not induce mRNA or activity of the different CYP450 enzymes and Bunex (Buprenorphine) with respect to the vehicle control; therefore, no clinically relevant induction of the tested CYP450 enzymes or MDR1 by fingolimod are expected at therapeutic concentrations. Similarly, they are not expected to inhibit the efflux of comedications andor biologics transported by the breast cancer resistant protein (MXR), Bunex (Buprenorphine) bile salt export pump (BSEP), the multidrug resistance-associated protein 2 (MRP2), and MDR1-mediated transport at therapeutic concentrations. No interaction studies have been performed with oral Bunex (Buprenorphine) containing other progestagens; however, an effect of fingolimod on their exposure is not expected. These data indicate that Gilenya is unlikely to reduce the clearance of drugs mainly cleared by CYP3A4 and show that the potent inhibition of transporters MDR1, MRP2, and OATP-C does not influence fingolimod disposition. Likewise, the single-dose pharmacokinetics of fingolimod and fingolimod-phosphate and the steady-state pharmacokinetics of Bunex (Buprenorphine) atenolol and diltiazem were unchanged during the coadministration of the latter 2 drugs individually with fingolimod.

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