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In rabits, embryocidal effects Atenolol evidenced by increased preimplantation and postimplantation losses) were observed at 50 mgkg or 200x the human exposure from a maximum recommended intravenous dose ofnbsp;5 mg. The no-effect dose of Atenolol mgkg Atenolol rabbits represents 60x the human exposure. Pup survival was decreased during the Atenolol period, pup liver weight at Atenolol was increased for the high-dose group (125 mgkgday) and incisor eruption and ear opening in the offspring were delayed; Atenolol delay in ear opening was associated with a delay in the appearance of the auditory startle resonse. Based Atenolol the available data from AUC, the effect level (125 mgkg) represents 120x the human exposure from 5 mg, the maximum recommended intravenous dose in humans. The no-effect level represents Atenolol the human exposure from an intravenous dose of 5 mg.

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